CYTOKINE STRUCTURAL TAXONOMY AND MECHANISMS OF RECEPTOR ENGAGEMENT

被引：241

作者：

SPRANG, SR ^{[1
]}

BAZAN, JF ^{[1
]}

机构：

[1] DNAX RES INST MOLEC & CELLULAR BIOL INC, PALO ALTO, CA 94304 USA

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1993年 / 3卷 / 06期

关键词：

D O I：

10.1016/0959-440X(93)90144-A

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Seven discrete families of cytokines have been identified by sequence and structural analysis. Within this diverse set of protein folds, the hematopoietic growth factors and tumor necrosis factor-like cytokines display a remarkable degree of variation upon their respective topological frameworks. In addition, prototype X-ray structures of ligand-receptor complexes reveal two different strategies of receptor engagement.

引用

页码：815 / 827

页数：13

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