STRUCTURE AND EVOLUTION OF INSULINS - IMPLICATIONS FOR RECEPTOR-BINDING

被引：86

作者：

MURRAYRUST, J ^{[1
]}

MCLEOD, AN ^{[1
]}

BLUNDELL, TL ^{[1
]}

WOOD, SP ^{[1
]}

机构：

[1] UNIV LONDON BIRKBECK COLL,DEPT CRYSTALLOG,IMPERIAL CANC RES FUND,STRUCT MOLEC BIOL UNIT,LONDON WC1E 7HX,ENGLAND

来源：

BIOESSAYS | 1992年 / 14卷 / 05期

关键词：

D O I：

10.1002/bies.950140507

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Insulin is a member of a family of hormones, growth factors and neuropeptides which are found in both vertebrates and invertebrates. A common 'insulin fold' is probably adopted by all family members. Although the specificities of receptor binding are different, there is a possibility of co-evolution of polypeptides and their receptors.

引用

收藏

页码：325 / 331

页数：7

相关论文

共 45 条

[1] STRUCTURE OF RHOMBOHEDRAL 2 ZINC INSULIN CRYSTALS [J].

ADAMS, MJ ;

BLUNDELL, TL ;

DODSON, EJ ;

DODSON, GG ;

VIJAYAN, M ;

BAKER, EN ;

HARDING, MM ;

HODGKIN, DC ;

RIMMER, B ;

SHEAT, S .

NATURE, 1969, 224 (5218) :491-&

[2] ON THE TERTIARY STRUCTURE OF THE EXTRACELLULAR DOMAINS OF THE EPIDERMAL GROWTH-FACTOR AND INSULIN-RECEPTORS [J].

BAJAJ, M ;

WATERFIELD, MD ;

SCHLESSINGER, J ;

TAYLOR, WR ;

BLUNDELL, T .

BIOCHIMICA ET BIOPHYSICA ACTA, 1987, 916 (02) :220-226

[3] THE STRUCTURE OF 2ZN PIG INSULIN CRYSTALS AT 1.5-A RESOLUTION [J].

BAKER, EN ;

BLUNDELL, TL ;

CUTFIELD, JF ;

CUTFIELD, SM ;

DODSON, EJ ;

DODSON, GG ;

HODGKIN, DMC ;

HUBBARD, RE ;

ISAACS, NW ;

REYNOLDS, CD ;

SAKABE, K ;

SAKABE, N ;

VIJAYAN, NM .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 1988, 319 (1195) :369-&

[4] RELAXIN HAS CONFORMATIONAL HOMOLOGY WITH INSULIN [J].

BEDARKAR, S ;

TURNELL, WG ;

BLUNDELL, TL ;

SCHWABE, C .

NATURE, 1977, 270 (5636) :449-451

[5]

Blundell T.L., 1972, ADV PROTEIN CHEM, V26, P279

[6] IS EVOLUTION OF INSULIN DARWINIAN OR DUE TO SELECTIVELY NEUTRAL MUTATION [J].

BLUNDELL, TL ;

WOOD, SP .

NATURE, 1975, 257 (5523) :197-203

[7] INSULIN-LIKE GROWTH-FACTOR - MODEL FOR TERTIARY STRUCTURE ACCOUNTING FOR IMMUNOREACTIVITY AND RECEPTOR-BINDING [J].

BLUNDELL, TL ;

BEDARKAR, S ;

RINDERKNECHT, E ;

HUMBEL, RE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1978, 75 (01) :180-184

[8] HORMONE FAMILIES - PANCREATIC HORMONES AND HOMOLOGOUS GROWTH-FACTORS [J].

BLUNDELL, TL ;

HUMBEL, RE .

NATURE, 1980, 287 (5785) :781-787

[9]

BLUNDELL TL, UNPUB

[10]

BREMS DN, 1991, J BIOL CHEM, V266, P1611

← 1 2 3 4 5 →