ANALOGS OF TETRAHYDROFOLIC ACID .39(1,2). SELECTIVE BROMOACYLATION OF POLYFUNCTIONAL MOLECULES FOR SYNTHESIS OF ACTIVE-SITE-DIRECTED IRREVERSIBLE ENZYME INHIBITORS

被引：46

作者：

BAKER, BR

SANTI, DV

COWARD, JK

SHAPIRO, HS

JORDAAN, JH

机构：

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1966年 / 3卷 / 04期

关键词：

D O I：

10.1002/jhet.5570030407

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

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页码：425 / &

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[11] ANALOGS OF TETRAHYDROFOLIC ACID .26. SYNTHESIS OF SOME 5-ARYL AND 5-ARALKYL PYRIMIDINE-6-CARBOXYLIC ACIDS AND THEIR EFFECT ON DIHYDROFOLIC REDUCTASE AND THYMIDYLATE SYNTHETASE [J].

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[12] ANALOGS OF TETRAHYDROFOLIC ACID .9. SYNTHESIS OF N-[1-(2-AMINO-4-HYDROXY-6-PHENYL-5-PYRIMIDYL)-3-PROPYL]-P-AMINOBENZOYL-L-GLUTAMIC ACID, A NONCLASSICAL INHIBITOR OF SOME FOLIC COFACTOR AREA ENZYMES [J].

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[13] SYNTHESIS OF 6-SUBSTITUTED PYRIMIDINES BY WITTIG REACTION .I. VIA 2-AMINO-4-HYDROXY-5-PHENYLBUTYLPYRIMIDINE-6-CARBOXALDEHYDE [J].

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[14] POTENTIAL ANTICANCER AGENTS .78. NONCLASSICAL ANTIMETABOLITES .4. SYNTHESIS OF COMPOUNDS RELATED TO 4-(IODOACETAMIDO)SALICYLIC ACID, AN EXO-ALKYLATING IRREVERSIBLE INHIBITOR [J].

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[15] ANALOGS OF TETRAHYDROFOLIC ACID .20. EFFECTS OF MODIFICATION OF BRIDGE BETWEEN PYRIMIDYL AND PHENYL MOIETIES OF 2-AMINO-5-(3-ANILINOPROPYL)-6-METHYL-4-PYRIMIDINOL ON INHIBITION OF DIHYDROFOLIC REDUCTASE AND THYMIDYLATE SYNTHETASE 2 [J].

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JOURNAL OF PHARMACEUTICAL SCIENCES, 1965, 54 (08) :1187-&

[16] ANALOGS OF TETRAHYDROFOLIC ACID .29. HYDROPHOBIC BONDING TO DIHYDROFOLIC REDUCTASE .2. ON MODE OF PHENYL BINDING OF 1-ARYL-4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-S-TRIAZINES [J].

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JOURNAL OF HETEROCYCLIC CHEMISTRY, 1965, 2 (04) :335-&

[17] ANALOGS OF TETRAHYDROFOLIC ACID .23. 1-(OMEGA-PHENYLALKYL)-4,6-DIAMINO-1,2-DIHYDRO-S-TRIAZINES AS INHIBITORS OF DIHYDROFOLIC REDUCTASE [J].

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JOURNAL OF HETEROCYCLIC CHEMISTRY, 1965, 2 (01) :72-&

[18] ANALOGS OF TETRAHYDROFOLOC ACID 34 - HYDROPHOBIC BONDING TO DIHYDROFOLOC REDUCTASE .6. MODE OF PHENYL BINDING OF SOME 6-ARYLPYRIMIDINES [J].

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JOURNAL OF PHARMACEUTICAL SCIENCES, 1966, 55 (03) :308-&

[19] ANALOGS OF TETRAHYDROFOLIC ACID .22. EFFECTS OF MODIFICATION OF BRIDGE BETWEEN PYRIMIDYL AND PHENYL MOIETIES OF 2-AMINO-5-(3-ANILINOPROPYL)-6-METHYL-4-PYRIMIDINOL ON INHIBITION OF DIHYDROFOLIC REDUCTASE AND THYMIDYLATE SYNTHETASE 3 [J].

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JOURNAL OF PHARMACEUTICAL SCIENCES, 1965, 54 (05) :714-&

[20] ANALOGS OF TETRAHYDROFOLIC ACID .18. ON MODE OF BINDING OF SOME 6-ARYL- AND 6-ARALKYLPYRIMIDINES TO FOLIC REDUCTASE [J].

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JOURNAL OF MEDICINAL CHEMISTRY, 1965, 8 (03) :283-+

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