ANALOGS OF TETRAHYDROFOLIC ACID .20. EFFECTS OF MODIFICATION OF BRIDGE BETWEEN PYRIMIDYL AND PHENYL MOIETIES OF 2-AMINO-5-(3-ANILINOPROPYL)-6-METHYL-4-PYRIMIDINOL ON INHIBITION OF DIHYDROFOLIC REDUCTASE AND THYMIDYLATE SYNTHETASE 2

被引：8

作者：

BAKER, BR

HO, B

机构：

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1965年 / 54卷 / 08期

关键词：

D O I：

10.1002/jps.2600540820

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：1187 / &

共 11 条

[1] ANALOGS OF TETRAHYDROFOLIC ACID .10. SYNTHETIC + ENZYMIC STUDIES ON CONTRIBUTION OF P-AMINOBENZOYL-L-GLUTAMATE MOIETY OF PYRIMIDYL ANALOGS TO BINDING TO SOME FOLIC COFACTOR AREA ENZYMES [J].

BAKER, BR ;

SANTI, DV ;

ALMAULA, PI ;

WERKHEISER, WC .

JOURNAL OF MEDICINAL CHEMISTRY, 1964, 7 (01) :24-&

[2] ANALOGS OF TETRAHYDROFOLIC ACID .8. SYNTHESIS OF N-[1-(2-AMINO-4-MERCAPTO-6-METHYL-5-PYRIMIDYL)-3-PROPYL]-P-AMINOBENZOYL-L-GLUTAMIC ACID, A MERCAPTO ANALOG [J].

BAKER, BR ;

HO, BT ;

MORREAL, CE .

JOURNAL OF MEDICINAL CHEMISTRY, 1963, 6 (06) :658-&

[3] FACTORS IN DESIGN OF ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS [J].

BAKER, BR .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1964, 53 (04) :347-&

[4] ANALOGS OF TETRAHYDROFOLIC ACID .22. EFFECTS OF MODIFICATION OF BRIDGE BETWEEN PYRIMIDYL AND PHENYL MOIETIES OF 2-AMINO-5-(3-ANILINOPROPYL)-6-METHYL-4-PYRIMIDINOL ON INHIBITION OF DIHYDROFOLIC REDUCTASE AND THYMIDYLATE SYNTHETASE 3 [J].

BAKER, BR ;

COWARD, JK .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1965, 54 (05) :714-&

[5] ANALOGS OF TETRAHYDROFOLIC ACID .11. - SYNTHESIS + ENZYMIC EVALUATION OF P- ( N-)2-AMINO-4-HYDROXY-6-METHYL-5-PYRIMIDYL ) CARBAMOYL METHYL ) AMINO ) BENZOYL-L-GLUTAMIC ACID [J].

BAKER, BR ;

SACHDEV, K .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1964, 53 (09) :1020-&

[6] ANALOGS OF TETRAHYDROFOLIC ACID .15. MODE OF BINDING OF 2,4-DIAMINOPYRIMIDINES TO FOLIC REDUCTASE + THYMIDYLATE SYNTHETASE [J].

BAKER, BR ;

HO, BT .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1964, 53 (12) :1457-&

[7] ANALOGS OF TETRAHYDROFOLIC ACID .17. ON MODE OF BINDING OF P-AMINOBENZOYL MOIETY OF N-(2-AMINO-4-HYDROXY-6-METHYL-5-PYRIMIDYLPROPYL)-P-AMINOBENZOYL-L-GLUTAMIC ACID TO DIHYDROFOLIC REDUCTASE [J].

BAKER, BR ;

JORDAAN, JH .

JOURNAL OF MEDICINAL CHEMISTRY, 1965, 8 (01) :35-&

[8]

BAKER BR, 1965, J HETEROCYCLIC CHEM, V1, P263

[9]

BAKER BR, 1964, J HETEROCYCLIC CHEM, V1, P88

[10]

BAKER BR, UNPUBLISHED DATA

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