Laser speckle contrast imaging in biomedical optics

被引：852

作者：

Boas, David A. ^{[1
]}

Dunn, Andrew K. ^{[2
]}

机构：

[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Anthinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA

[2] Univ Texas Austin, Dept Biomed Engn, Austin, TX 78712 USA

来源：

JOURNAL OF BIOMEDICAL OPTICS | 2010年 / 15卷 / 01期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

laser speckle contrast; blood flow; biomedical imaging; CEREBRAL-BLOOD-FLOW; RAT BARREL CORTEX; CORTICAL SPREADING DEPRESSION; FUNCTIONAL ACTIVATION; PERIINFARCT DEPOLARIZATIONS; SOMATOSENSORY CORTEX; LIGHT-SCATTERING; NERVE HEAD; 2-DIMENSIONAL MEASUREMENT; DOPPLER MEASUREMENTS;

D O I：

10.1117/1.3285504

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

First introduced in the 1980s, laser speckle contrast imaging is a powerful tool for full-field imaging of blood flow. Recently laser speckle contrast imaging has gained increased attention, in part due to its rapid adoption for blood flow studies in the brain. We review the underlying physics of speckle contrast imaging and discuss recent developments to improve the quantitative accuracy of blood flow measures. We also review applications of laser speckle contrast imaging in neuroscience, dermatology and ophthalmology. (C) 2010 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3285504]

引用

页数：12

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