Hypoxia and metabolism - Opinion - The interplay between MYC and HIF in cancer

被引：473

作者：

Dang, Chi V. ^{[1
,2
,3
]}

Kim, Jung-whan ^{[1
]}

Gao, Ping ^{[1
]}

Yustein, Jason ^{[4
,5
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Med, Div Hematol, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Dept Cell Biol, Dept Oncol, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprehens Canc Ctr Johns Hopkins, Baltimore, MD 21205 USA

[5] Johns Hopkins Univ, Sch Med, Dept Pediat, Baltimore, MD 21205 USA

来源：

NATURE REVIEWS CANCER | 2008年 / 8卷 / 01期

关键词：

D O I：

10.1038/nrc2274

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The interaction of MYC and hypoxia inducible factors (HIFs) under physiological, non-tumorigenic conditions provides insights into normal homeostatic cellular responses to low oxygen levels (hypoxia). Many tumours contain genetic alterations, such as MYC activation, that can collaborate with HIF to confer metabolic advantages to tumour cells, which tend to exist in a hypoxic microenvironment. This Perspective emphasizes the differences between the transcriptional network that operates under normal homeostatic conditions and the network in a tumorigenic milieu.

引用

页码：51 / 56

页数：6

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