Antagonism of Myc functions by Arf

被引：35

作者：

Cleveland, JL

Sherr, CJ ^{[1
]}

机构：

[1] St Jude Childrens Res Hosp, Dept Biochem, Memphis, TN 38105 USA

[2] St Jude Childrens Res Hosp, Dept Genet & Tumor Cell Biol, Memphis, TN 38105 USA

[3] St Jude Childrens Res Hosp, Howard Hughes Med Inst, Memphis, TN 38105 USA

来源：

CANCER CELL | 2004年 / 6卷 / 04期

关键词：

D O I：

10.1016/j.ccr.2004.09.020

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The Arf-Mdm2-p53 tumor suppressor pathway is activated by sustained hyperproliferative signals emanating from oncoproteins such as Myc. A recent study reveals a novel level of feedback control, whereby induced p19(Arf) binds to Myc and blocks cell proliferation by selectively impairing its transactivation functions.

引用

收藏

页码：309 / 311

页数：3

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