Hypoxia signalling controls metabolic demand

被引：246

作者：

Brahimi-Horn, M. Christiane ^{[1
]}

Chiche, Johanna ^{[1
]}

Pouyssegur, Jacques ^{[1
]}

机构：

[1] Univ Nice, Inst Signaling Dev Biol & Canc Res, CNRS, Ctr A Lacassagne,UMR 6543, F-06189 Nice, France

来源：

CURRENT OPINION IN CELL BIOLOGY | 2007年 / 19卷 / 02期

关键词：

D O I：

10.1016/j.ceb.2007.02.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

It has been known for quite some time that cancer cells undergo far-reaching modifications in their metabolism, yet a full understanding of these changes and how they come about remains elusive. Even under conditions of plentiful oxygen, cancer cells choose to switch glucose metabolism from respiration to lactic acid formation. The mystery behind the molecular mechanisms of this phenomenon, known as the Warburg effect, is now being unravelled. The reduced respiration rate and increased glucose uptake associated with lactic acid production, and acidosis of the micro-environment, are primarily due to activation of the alpha/beta hypoxia-inducible transcription factor. This distinctive metabolic nature of cancer cells is already being exploited as a diagnostic tool but is yet to be harnessed as a therapeutic intervention.

引用

页码：223 / 229

页数：7

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