CDD: specific functional annotation with the Conserved Domain Database

被引：875

作者：

Marchler-Bauer, Aron ^{[1
]}

Anderson, John B. ^{[1
]}

Chitsaz, Farideh ^{[1
]}

Derbyshire, Myra K. ^{[1
]}

DeWeese-Scott, Carol ^{[1
]}

Fong, Jessica H. ^{[1
]}

Geer, Lewis Y. ^{[1
]}

Geer, Renata C. ^{[1
]}

Gonzales, Noreen R. ^{[1
]}

Gwadz, Marc ^{[1
]}

He, Siqian ^{[1
]}

Hurwitz, David I. ^{[1
]}

Jackson, John D. ^{[1
]}

Ke, Zhaoxi ^{[1
]}

Lanczycki, Christopher J. ^{[1
]}

Liebert, Cynthia A. ^{[1
]}

Liu, Chunlei ^{[1
]}

Lu, Fu ^{[1
]}

Lu, Shennan ^{[1
]}

Marchler, Gabriele H. ^{[1
]}

Mullokandov, Mikhail ^{[1
]}

Song, James S. ^{[1
]}

Tasneem, Asba ^{[1
]}

Thanki, Narmada ^{[1
]}

Yamashita, Roxanne A. ^{[1
]}

Zhang, Dachuan ^{[1
]}

Zhang, Naigong ^{[1
]}

Bryant, Stephen H. ^{[1
]}

机构：

[1] Natl Lib Med, Natl Ctr Biotechnol Informat, NIH, Bethesda, MD 20894 USA

来源：

NUCLEIC ACIDS RESEARCH | 2009年 / 37卷

基金：

美国国家卫生研究院;

关键词：

ALIGNMENTS;

D O I：

10.1093/nar/gkn845

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

NCBI's Conserved Domain Database (CDD) is a collection of multiple sequence alignments and derived database search models, which represent protein domains conserved in molecular evolution. The collection can be accessed at http://www.ncbi.nlm.nih.gov/Structure/cdd/cdd.shtml, and is also part of NCBI's Entrez query and retrieval system, crosslinked to numerous other resources. CDD provides annotation of domain footprints and conserved functional sites on protein sequences. Precalculated domain annotation can be retrieved for protein sequences tracked in NCBI's Entrez system, and CDD's collection of models can be queried with novel protein sequences via the CD-Search service at http://www.ncbi.nlm.nih.gov/Structure/cdd/wrpsb.cgi. Starting with the latest version of CDD, v2.14, information from redundant and homologous domain models is summarized at a superfamily level, and domain annotation on proteins is flagged as either 'specific' ( identifying molecular function with high confidence) or as 'non-specific' (identifying superfamily membership only).

引用

页码：D205 / D210

页数：6

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