CDART: Protein homology by domain architecture

被引：557

作者：

Geer, LY ^{[1
]}

Domrachev, M ^{[1
]}

Lipman, DJ ^{[1
]}

Bryant, SH ^{[1
]}

机构：

[1] NIH, Natl Ctr Biotechnol Informat, Natl Lib Med, Bethesda, MD 20894 USA

来源：

GENOME RESEARCH | 2002年 / 12卷 / 10期

关键词：

D O I：

10.1101/gr.278202

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Conserved Domain Architecture Retrieval Tool (CDART) performs similarity searches of the NCBl Entrez Protein Database based on domain architecture, defined as the sequential order of conserved domains in proteins. The algorithm finds protein similarities across significant evolutionary distances using sensitive protein domain profiles rather than by direct sequence similarity. Proteins similar to a query protein are grouped and scored by architecture. Relying on domain profiles allows CDART to be fast, and, because it relies on annotated functional domains, informative. Domain profiles are derived from several collections of domain definitions that include functional annotation. Searches can be further refined by taxonomy and by selecting domains of interest. CDART is available at http://www.ncbi.nlm.nih.gov/Structure/lexington/lexington.cgi.

引用

页码：1619 / 1623

页数：5

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