SMART 5: domains in the context of genomes and networks

被引：798

作者：

Letunic, Ivica

Copley, Richard R.

Pils, Birgit

Pinkert, Stefan

Schultz, Joerg

Bork, Peer

机构：

[1] European Mol Biol Lab, D-69012 Heidelberg, Germany

[2] Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England

[3] Univ Wurzburg, Biozentrum, D-97074 Wurzburg, Germany

来源：

NUCLEIC ACIDS RESEARCH | 2006年 / 34卷

关键词：

D O I：

10.1093/nar/gkj079

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Simple Modular Architecture Research Tool (SMART) is an online resource (http://smart.embl.de/) used for protein domain identification and the analysis of protein domain architectures. Many new features were implemented to make SMART more accessible to scientists from different fields. The new 'Genomic' mode in SMART makes it easy to analyze domain architectures in completely sequenced genomes. Domain annotation has been updated with a detailed taxonomic breakdown and a prediction of the catalytic activity for 50 SMART domains is now available, based on the presence of essential amino acids. Furthermore, intrinsically disordered protein regions can be identified and displayed. The network context is now displayed in the results page for more than 350000 proteins, enabling easy analyses of domain interactions.

引用

页码：D257 / D260

页数：4

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