Rfam: updates to the RNA families database

被引：795

作者：

Gardner, Paul P. ^{[1
]}

Daub, Jennifer ^{[1
]}

Tate, John G. ^{[1
]}

Nawrocki, Eric P. ^{[2
]}

Kolbe, Diana L. ^{[2
]}

Lindgreen, Stinus ^{[3
]}

Wilkinson, Adam C. ^{[1
]}

Finn, Robert D. ^{[1
]}

Griffiths-Jones, Sam ^{[4
]}

Eddy, Sean R. ^{[2
]}

Bateman, Alex ^{[1
]}

机构：

[1] Wellcome Trust Sanger Inst, Hinxton CB10 1SA, England

[2] Howard Hughes Med Inst, Ashburn, VA USA

[3] Univ Copenhagen, Dept Biol, Ctr Bioinformat, DK-2200 Copenhagen N, Denmark

[4] Univ Manchester, Fac Life Sci, Manchester M13 9PL, Lancs, England

来源：

NUCLEIC ACIDS RESEARCH | 2009年 / 37卷

基金：

英国惠康基金;

关键词：

PREDICTION; SEQUENCE; TOOLS;

D O I：

10.1093/nar/gkn766

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Rfam is a collection of RNA sequence families, represented by multiple sequence alignments and covariance models (CMs). The primary aim of Rfam is to annotate new members of known RNA families on nucleotide sequences, particularly complete genomes, using sensitive BLAST filters in combination with CMs. A minority of families with a very broad taxonomic range (e.g. tRNA and rRNA) provide the majority of the sequence annotations, whilst the majority of Rfam families (e.g. snoRNAs and miRNAs) have a limited taxonomic range and provide a limited number of annotations. Recent improvements to the website, methodologies and data used by Rfam are discussed. Rfam is freely available on the Web at http://rfam.sanger.ac.uk/ and http://rfam.janelia.org/.

引用

页码：D136 / D140

页数：5

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