Rfam: annotating non-coding RNAs in complete genomes

被引：1274

作者：

Griffiths-Jones, S

Moxon, S

Marshall, M

Khanna, A

Eddy, SR

Bateman, A

机构：

[1] Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England

[2] Washington Univ, Sch Med, Howard Hughes Med Inst, St Louis, MO 63108 USA

[3] Washington Univ, Sch Med, Dept Genet, St Louis, MO 63108 USA

来源：

NUCLEIC ACIDS RESEARCH | 2005年 / 33卷

关键词：

D O I：

10.1093/nar/gki081

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Rfam is a comprehensive collection of non-coding RNA (ncRNA) families, represented by multiple sequence alignments and profile stochastic context-free grammars. Rfam aims to facilitate the identification and classification of new members of known sequence families, and distributes annotation of ncRNAs in over 200 complete genome sequences. The data provide the first glimpses of conservation of multiple ncRNA families across a wide taxonomic range. A small number of large families are essential in all three kingdoms of life, with large numbers of smaller families specific to certain taxa. Recent improvements in the database are discussed, together with challenges for the future. Rfam is available on the Web at http://www.sanger.ac.uk/Software/Rfam/ and http://rfam.wustl.edu/.

引用

收藏

页码：D121 / D124

页数：4

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