Rfam: an RNA family database

被引:1160
作者
Griffiths-Jones, S
Bateman, A
Marshall, M
Khanna, A
Eddy, SR
机构
[1] Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England
[2] Washington Univ, Sch Med, Howard Hughes Med Inst, St Louis, MO 63110 USA
[3] Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA
关键词
D O I
10.1093/nar/gkg006
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Rfam is a collection of multiple sequence alignments and covariance models representing non- coding RNA families. Rfam is available on the web in the UK at http: / / www. sanger. ac. uk/ Software/ Rfam/ and in the US at http: / / rfam. wustl. edu/. These websites allow the user to search a query sequence against a library of covariance models, and view multiple sequence alignments and family annotation. The database can also be downloaded in at le form and searched locally using the INFERNAL package ( http: / / infernal. wustl. edu/). The first release of Rfam ( 1.0) contains 25 families, which annotate over 50 000 non- coding RNA genes in the taxonomic divisions of the EMBL nucleotide database.
引用
收藏
页码:439 / 441
页数:3
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