炎性因素与缺血性卒中

被引：4

作者：

李继梅

刘水乔

机构：

[1] 首都医科大学附属北京友谊医院神经内科

来源：

中国卒中杂志 | 2013年 / 8卷 / 04期

关键词：

缺血性卒中; 炎性因子; 动脉粥样硬化; 感染; 靶向治疗;

D O I：

暂无

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

1002 ;

摘要：

<正>卒中位列全球人口全因死亡率的第4位,尤其在低、中等收入国家,其发病率仍在不断地升高[1],其中以动脉粥样硬化为基础的缺血性卒中发病率具有逐年增多的趋势[2]。动脉粥样硬化实质上是一种由数十种炎性因子介导的炎症免疫反应[3],其发生、发展及预后均与炎症反应密切相关。因此,调节炎症反应过程、以炎性

引用

收藏

页码：241 / 245

页数：5

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共 15 条

[1] 不同病因和发病机制首次急性缺血性卒中患者超敏C反应蛋白的变化 [J].

史哲 ;

王拥军 .

中国卒中杂志, 2013, 8 (02) :106-110

[2] 急性脑梗死与超敏C反应蛋白的关系 [J].

林晓东 ;

赵丽 ;

王学敏 ;

王海英 ;

田小卫 ;

李福学 .

中华脑血管病杂志(电子版), 2009, 3 (01) :17-19

[3]

Novel therapeutic strategies targeting innate immune responses and early inflammation after stroke[J] . Takashi Shichita,Tetsuro Ago,Masahiro Kamouchi,Takanari Kitazono,Akihiko Yoshimura,Hiroaki Ooboshi.J. Neurochem. . 2012

[4] Inflammatory cytokines in experimental and human stroke [J].

Lambertsen, Kate Lykke ;

Biber, Knut ;

Finsen, Bente .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2012, 32 (09) :1677-1698

[5] Delayed administration of interleukin-1 receptor antagonist reduces ischemic brain damage and inflammation in comorbid rats [J].

Pradillo, Jesus M. ;

Denes, Adam ;

Greenhalgh, Andrew D. ;

Boutin, Herve ;

Drake, Caroline ;

McColl, Barry W. ;

Barton, Eleanor ;

Proctor, Spencer D. ;

Russell, James C. ;

Rothwell, Nancy J. ;

Allan, Stuart M. .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2012, 32 (09) :1810-1819

[6] Interleukin-1 Mediates Neuroinflammatory Changes Associated With Diet-Induced Atherosclerosis [J].

Denes, Adam ;

Drake, Caroline ;

Stordy, Jing ;

Chamberlain, Janet ;

McColl, Barry W. ;

Gram, Hermann ;

Crossman, David ;

Francis, Sheila ;

Allan, Stuart M. ;

Rothwell, Nancy J. .

JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2012, 1 (03)

[7] Autoimmune Responses to the Brain After Stroke Are Associated With Worse Outcome [J].

Becker, Kyra J. ;

Kalil, Angela J. ;

Tanzi, Pat ;

Zierath, Dannielle K. ;

Savos, Anna V. ;

Gee, J. Michael ;

Hadwin, Jessica ;

Carter, Kelly T. ;

Shibata, Dean ;

Cain, Kevin C. .

STROKE, 2011, 42 (10) :2763-U133

[8] SEARCH FOR GENOMIC SEQUENCES OF MICROBIAL AGENTS IN ATHEROSCLEROTIC PLAQUES [J].

Tremolada, S. ;

Delbue, S. ;

Ferraresso, M. ;

Carloni, C. ;

Elia, F. ;

Larocca, S. ;

Bortolani, E. ;

Ferrante, P. .

INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY, 2011, 24 (01) :243-246

[9] Systemic and Intraplaque Mediators of Inflammation Are Increased in Patients Symptomatic for Ischemic Stroke [J].

Montecucco, Fabrizio ;

Lenglet, Sebastien ;

Gayet-Ageron, Angele ;

Bertolotto, Maria ;

Pelli, Graziano ;

Palombo, Domenico ;

Pane, Bianca ;

Spinella, Giovanni ;

Steffens, Sabine ;

Raffaghello, Lizzia ;

Pistoia, Vito ;

Ottonello, Luciano ;

Pende, Aldo ;

Dallegri, Franco ;

Mach, Francois .

STROKE, 2010, 41 (07) :1394-1404

[10] Systematic Review and Stratified Meta-analysis of the Efficacy of Interleukin-1 Receptor Antagonist in Animal Models of Stroke [J].

Banwell, Victoria ;

Sena, Emily S. ;

Macleod, Malcolm R. .

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 2009, 18 (04) :269-276