[1] Univ Manchester, Fac Life Sci, Manchester, Lancs, England
[2] Univ Sheffield, Sch Med, Dept Cardiovasc Sci, Sheffield, S Yorkshire, England
[3] Univ Edinburgh, Roslin Inst, Edinburgh EH8 9YL, Midlothian, Scotland
[4] Univ Edinburgh, RDSVS, Edinburgh EH8 9YL, Midlothian, Scotland
[5] Univ E Anglia, Norwich Med Sch, Norwich NR4 7TJ, Norfolk, England
[6] Novartis Inst BioMed Res, Basel, Switzerland