A SIGNALING PATHWAY GOVERNING EARLY THYMOCYTE MATURATION

被引:69
作者
ANDERSON, SJ
PERLMUTTER, RM
机构
[1] UNIV WASHINGTON, DEPT IMMUNOL, SEATTLE, WA 98195 USA
[2] UNIV WASHINGTON, DEPT BIOCHEM, SEATTLE, WA 98195 USA
[3] UNIV WASHINGTON, DEPT MED, DIV MED GENET, SEATTLE, WA 98195 USA
来源
IMMUNOLOGY TODAY | 1995年 / 16卷 / 02期
关键词
D O I
10.1016/0167-5699(95)80096-4
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Recent evidence supports the view that p56(lck), a non-receptor protein tyrosine Kinase, serves as the signaling element that 'senses' synthesis of a functional T-cell receptor beta chain, thereby promoting thymocyte maturation. Here, Steven Anderson and Roger Perlmutter review current data, and outline the features of this developmental program.
引用
收藏
页码:99 / 105
页数:7
相关论文
共 60 条
[41]  
OWEN JJT, 1988, IMMUNOLOGY, V63, P639
[42]   A MURINE EARLY THYMOCYTE DEVELOPMENTAL SEQUENCE IS MARKED BY TRANSIENT EXPRESSION OF THE INTERLEUKIN-2 RECEPTOR [J].
PEARSE, M ;
WU, L ;
EGERTON, M ;
WILSON, A ;
SHORTMAN, K ;
SCOLLAY, R .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (05) :1614-1618
[43]   EARLY LYMPHOCYTE EXPANSION IS SEVERELY IMPAIRED IN INTERLEUKIN-7 RECEPTOR-DEFICIENT MICE [J].
PESCHON, JJ ;
MORRISSEY, PJ ;
GRABSTEIN, KH ;
RAMSDELL, FJ ;
MARASKOVSKY, E ;
GLINIAK, BC ;
PARK, LS ;
ZIEGLER, SF ;
WILLIAMS, DE ;
WARE, CB ;
MEYER, JD ;
DAVISON, BL .
JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 180 (05) :1955-1960
[44]   LYMPHOID DEVELOPMENT IN MICE CONGENITALLY LACKING T-CELL RECEPTOR-ALPHA-BETA EXPRESSING CELLS [J].
PHILPOTT, KL ;
VINEY, JL ;
KAY, G ;
RASTAN, S ;
GARDINER, EM ;
CHAE, S ;
HAYDAY, AC ;
OWEN, MJ .
SCIENCE, 1992, 256 (5062) :1448-1452
[45]   DEVELOPMENTAL REGULATION OF T-CELL RECEPTOR GENE-EXPRESSION [J].
RAULET, DH ;
GARMAN, RD ;
SAITO, H ;
TONEGAWA, S .
NATURE, 1985, 314 (6006) :103-107
[46]  
ROTHENBERG EV, 1993, J IMMUNOL, V151, P3530
[47]   ANALYSIS AND EXPRESSION OF A CLONED PRE-T CELL-RECEPTOR GENE [J].
SAINTRUF, C ;
UNGEWISS, K ;
GROETTRUP, M ;
BRUNO, L ;
FEHLING, HJ ;
VONBOEHMER, H .
SCIENCE, 1994, 266 (5188) :1208-1212
[48]   DOUBLE-STRAND SIGNAL SEQUENCE BREAKS IN V(D)J RECOMBINATION ARE BLUNT, 5'-PHOSPHORYLATED, RAG-DEPENDENT, AND CELL-CYCLE-REGULATED [J].
SCHLISSEL, M ;
CONSTANTINESCU, A ;
MORROW, T ;
BAXTER, M ;
PENG, A .
GENES & DEVELOPMENT, 1993, 7 (12B) :2520-2532
[49]  
SCHULER W, 1989, CURR TOP MICROBIOL, V152, P55
[50]   DEVELOPMENTAL STATUS AND RECONSTITUTION POTENTIAL OF SUBPOPULATIONS OF MURINE THYMOCYTES [J].
SCOLLAY, R ;
WILSON, A ;
DAMICO, A ;
KELLY, K ;
EGERTON, M ;
PEARSE, M ;
WU, L ;
SHORTMAN, K .
IMMUNOLOGICAL REVIEWS, 1988, 104 :81-120