ANALYSIS AND EXPRESSION OF A CLONED PRE-T CELL-RECEPTOR GENE

被引：354

作者：

SAINTRUF, C ^{[1
]}

UNGEWISS, K ^{[1
]}

GROETTRUP, M ^{[1
]}

BRUNO, L ^{[1
]}

FEHLING, HJ ^{[1
]}

VONBOEHMER, H ^{[1
]}

机构：

[1] BASEL INST IMMUNOL,CH-4005 BASEL,SWITZERLAND

来源：

SCIENCE | 1994年 / 266卷 / 5188期

关键词：

D O I：

10.1126/science.7973703

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The T cell antigen receptor (TCR) beta chain regulates early T cell development in the absence of the TCR alpha chain. The developmentally controlled gene described here encodes the pre-TCR alpha (pT alpha) chain, which covalently associates with TCR beta and with the CD3 proteins forms a pre-TCR complex that transduces signals in immature thymocytes. Unlike the lambda 5 pre-B cell receptor protein, the pT alpha chain is a type I transmembrane protein whose cytoplasmic tail contains two potential phosphorylation sites and a Src homology 3 (SH3)-domain binding sequence. Pre-TCR alpha transfection experiments indicated that surface expression of the pre-TCR is controlled by additional developmentally regulated proteins. Identification of the pT alpha gene represents an essential step in the structure-function analysis of the pre-TCR complex.

引用

页码：1208 / 1212

页数：5

共 38 条

[1] INHIBITION OF T-CELL RECEPTOR BETA-CHAIN GENE REARRANGEMENT BY OVEREXPRESSION OF THE NONRECEPTOR PROTEIN TYROSINE KINASE-P56LCK [J].