A SIGNALING PATHWAY GOVERNING EARLY THYMOCYTE MATURATION

被引：69

作者：

ANDERSON, SJ

PERLMUTTER, RM

机构：

[1] UNIV WASHINGTON, DEPT IMMUNOL, SEATTLE, WA 98195 USA

[2] UNIV WASHINGTON, DEPT BIOCHEM, SEATTLE, WA 98195 USA

[3] UNIV WASHINGTON, DEPT MED, DIV MED GENET, SEATTLE, WA 98195 USA

来源：

IMMUNOLOGY TODAY | 1995年 / 16卷 / 02期

关键词：

D O I：

10.1016/0167-5699(95)80096-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent evidence supports the view that p56(lck), a non-receptor protein tyrosine Kinase, serves as the signaling element that 'senses' synthesis of a functional T-cell receptor beta chain, thereby promoting thymocyte maturation. Here, Steven Anderson and Roger Perlmutter review current data, and outline the features of this developmental program.

引用

收藏

页码：99 / 105

页数：7

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