INVERTED REPEAT STRUCTURE OF THE SRY LOCUS IN MICE

被引：163

作者：

GUBBAY, J

VIVIAN, N

ECONOMOU, A

JACKSON, D

GOODFELLOW, P

LOVELLBADGE, R

机构：

[1] NATL INST MED RES,EUKARYOT MOLEC GENET LAB,MILL HILL,LONDON NW7 1AA,ENGLAND

[2] IMPERIAL CANC RES FUND,HUMAN MOLEC GENET LAB,LONDON WC2A 3PX,ENGLAND

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1992年 / 89卷 / 17期

基金：

英国医学研究理事会;

关键词：

TESTIS DETERMINATION; TDY(M1); DELETION; Y-CHROMOSOME;

D O I：

10.1073/pnas.89.17.7953

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The testis-determining gene Sry is located on the short arm of the mouse Y chromosome in a region known to have undergone duplications and rearrangements in comparison with the equivalent portion of the human Y chromosome. Detailed analysis of the Sry genomic locus reveals a further difference in that the mouse Sry open reading frame lies within 2.8 kilobases of unique sequence at the center of a large inverted repeat. This repeat, which is found in both Mus musculus musculus and Mus musculus domesticus Y chromosomes, is not present at the human SRY locus. Recombination involving the repeat region may have led to an 11-kilobase deletion, precisely excising Sry in a line of XY female mice.

引用

页码：7953 / 7957

页数：5

共 41 条

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