A GENE-MAPPING TO THE SEX-DETERMINING REGION OF THE MOUSE Y-CHROMOSOME IS A MEMBER OF A NOVEL FAMILY OF EMBRYONICALLY EXPRESSED GENES

被引:1431
作者
GUBBAY, J [1 ]
COLLIGNON, J [1 ]
KOOPMAN, P [1 ]
CAPEL, B [1 ]
ECONOMOU, A [1 ]
MUNSTERBERG, A [1 ]
VIVIAN, N [1 ]
GOODFELLOW, P [1 ]
LOVELLBADGE, R [1 ]
机构
[1] IMPERIAL CANC RES FUND,HUMAN MOLEC GENET LAB,LONDON WC2A 3PX,ENGLAND
基金
英国医学研究理事会;
关键词
D O I
10.1038/346245a0
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
A gene mapping to the sex-determining region of the mouse Y chromosome is deleted in a line of XY female mice mutant for Tdy, and is expressed at a stage during male gonadal development consistent with its having a role in testis determination. This gene is a member of a new family of at least five mouse genes, related by an amino-acid motif showing homology to other known or putative DNA-binding domains. © 1990 Nature Publishing Group.
引用
收藏
页码:245 / 250
页数:6
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