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INVERTED REPEAT STRUCTURE OF THE SRY LOCUS IN MICE

被引：163
作者：
GUBBAY, J
VIVIAN, N
ECONOMOU, A
JACKSON, D
GOODFELLOW, P
LOVELLBADGE, R
机构：
[1] NATL INST MED RES,EUKARYOT MOLEC GENET LAB,MILL HILL,LONDON NW7 1AA,ENGLAND
[2] IMPERIAL CANC RES FUND,HUMAN MOLEC GENET LAB,LONDON WC2A 3PX,ENGLAND
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1992年 / 89卷 / 17期
基金：
英国医学研究理事会;
关键词：
TESTIS DETERMINATION; TDY(M1); DELETION; Y-CHROMOSOME;
D O I：
10.1073/pnas.89.17.7953
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The testis-determining gene Sry is located on the short arm of the mouse Y chromosome in a region known to have undergone duplications and rearrangements in comparison with the equivalent portion of the human Y chromosome. Detailed analysis of the Sry genomic locus reveals a further difference in that the mouse Sry open reading frame lies within 2.8 kilobases of unique sequence at the center of a large inverted repeat. This repeat, which is found in both Mus musculus musculus and Mus musculus domesticus Y chromosomes, is not present at the human SRY locus. Recombination involving the repeat region may have led to an 11-kilobase deletion, precisely excising Sry in a line of XY female mice.
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收藏
页码：7953 / 7957
页数：5
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