RELEASE OF EXCESS AMYLOID BETA-PROTEIN FROM A MUTANT AMYLOID BETA-PROTEIN PRECURSOR

被引：857

作者：

CAI, XD ^{[1
]}

GOLDE, TE ^{[1
]}

YOUNKIN, SG ^{[1
]}

机构：

[1] CASE WESTERN RESERVE UNIV, INST PATHOL, DIV NEUROPATHOL, CLEVELAND, OH 44106 USA

来源：

SCIENCE | 1993年 / 259卷 / 5094期

关键词：

D O I：

10.1126/science.8424174

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The 4-kilodalton amyloid beta protein (Abeta), which forms fibrillar deposits in Alzheimer's disease (AD), is derived from a large protein referred to as the amyloid beta protein precursor (betaAPP). Human neuroblastoma (M17) cells transfected with constructs expressing wild-type betaAPP or a mutant, betaAPP(DELTANL), recently linked to familial AD were compared. After continuous metabolic labeling for 8 hours, cells expressing betaAPP(DELTANL) had five times more of an Abeta-bearing, carboxyl terminal, betaAPP derivative than cells expressing wild-type betaAPP and they released six times more Abeta into the medium. Thus this mutant betaAPP may cause AD because its processing is altered in a way that releases increased amounts of Abeta.

引用

页码：514 / 516

页数：3

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