POTENTIALLY AMYLOIDOGENIC, CARBOXYL-TERMINAL DERIVATIVES OF THE AMYLOID PROTEIN-PRECURSOR

被引：408

作者：

ESTUS, S

GOLDE, TE

KUNISHITA, T

BLADES, D

LOWERY, D

EISEN, M

USIAK, M

QU, XM

TABIRA, T

GREENBERG, BD

YOUNKIN, SG

机构：

[1] NATL INST NEUROSCI,KODAIRA,TOKYO 187,JAPAN

[2] UPJOHN CO,KALAMAZOO,MI 49001

来源：

SCIENCE | 1992年 / 255卷 / 5045期

关键词：

D O I：

10.1126/science.1738846

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The 39- to 43-amino acid amyloid beta-protein (beta-AP), which is deposited as amyloid in Alzheimer's disease, is encoded as an internal peptide that begins 99 residues from the carboxyl terminus of a 695- to 770-amino acid glycoprotein referred to as the amyloid beta-protein precursor (beta-APP). To clarify the processing that produces amyloid, carboxyl-terminal derivatives of the beta-APP were analyzed. This analysis showed that the beta-APP is normally processed into a complex set of 8- to 12-kilodalton carboxyl-terminal derivatives. The two largest derivatives in human brain have the entire beta-AP at or near their amino terminus and are likely to be intermediates in the pathway leading to amyloid deposition.

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页码：726 / 728

页数：3

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