CLEAVAGE OF AMYLOID-BETA PEPTIDE DURING CONSTITUTIVE PROCESSING OF ITS PRECURSOR

被引：1336

作者：

ESCH, FS ^{[1
]}

KEIM, PS ^{[1
]}

BEATTIE, EC ^{[1
]}

BLACHER, RW ^{[1
]}

CULWELL, AR ^{[1
]}

OLTERSDORF, T ^{[1
]}

MCCLURE, D ^{[1
]}

WARD, PJ ^{[1
]}

机构：

[1] ELI LILLY INT CORP,LILLY CORP CTR,INDIANAPOLIS,IN 46285

来源：

SCIENCE | 1990年 / 248卷 / 4959期

关键词：

D O I：

10.1126/science.2111583

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The amyloid β peptide (AβP) is a small fragment of the much larger, broadly distributed amyloid precursor protein (APP). Abundant AβP deposition in the brains of patients with Alzheimer's disease suggests that altered APP processing may represent a key pathogenic event. Direct protein structural analyses showed that constitutive processing in human embryonic kidney 293 cells cleaves APP in the interior of the AβP, thus preventing AβP deposition. A defciency of this processing event may ultimately prove to be the etiological event in Alzheimer's disease that gives rise to senile plaque formation.

引用

页码：1122 / 1124

页数：3

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