DRUG-THERAPY - CANDIDATE AIDS VACCINES

There is an urgent need to control the global epidemic of human immunodeficiency virus type 1 (HIV-1) infection. Although educational approaches to modify risk-taking behavior are a critical component of prevention, we focus this discussion on the status of vaccine development. The success of active immunization against other infectious diseases makes immunization an attractive approach to preventing HIV-1 infection. The eradication of smallpox1 and progress in the elimination of poliomyelitis, targeted to occur by the year 2000,2 are notable examples of the impact of vaccination. Given the complexity of HIV-1 pathogenesis, however, empirical approaches successful in the development of previous. © 1995, Massachusetts Medical Society. All rights reserved.