HUMAN-IMMUNODEFICIENCY-VIRUS GENETIC-VARIATION THAT CAN ESCAPE CYTOTOXIC T-CELL RECOGNITION

被引：970

作者：

PHILLIPS, RE

ROWLANDJONES, S

NIXON, DF

GOTCH, FM

EDWARDS, JP

OGUNLESI, AO

ELVIN, JG

ROTHBARD, JA

BANGHAM, CRM

RIZZA, CR

MCMICHAEL, AJ

机构：

[1] IMMULOGIC, PALO ALTO, CA 94304 USA

[2] CHURCHILL HOSP, OXFORD HAEMOPHILIA CTR, OXFORD OX3 7LV, ENGLAND

来源：

NATURE | 1991年 / 354卷 / 6353期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/354453a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In a longitudinal study of HIV seropositive patients, there were fluctuations in the specificity of cytotoxic T cells for the virus. This was matched by variability in proviral gag DNA epitope sequences in the lymphocytes of these patients. Some of these viral variants are not recognized by autologous T cells. Accumulation of such mutations in T-cell antigenic targets would provide a mechanism for immune escape.

引用

页码：453 / 459

页数：7

共 43 条

[1] USE OF SYNTHETIC PEPTIDES OF INFLUENZA NUCLEOPROTEIN TO DEFINE EPITOPES RECOGNIZED BY CLASS-I-RESTRICTED CYTOTOXIC LYMPHOCYTES-T [J].