Sex reversal in C57BL/6J-Y-POS mice corrected by a Sry transgene

被引:61
作者
Eicher, EM
Shown, EP
Washburn, LL
机构
[1] Jackson Laboratory, Bar Harbor, 04609, Maine
关键词
D O I
10.1098/rstb.1995.0160
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
C57BL/6J mice carrying a Mus domesticus poschiavinus Y chromosome (Y-POS) develop as females with ovarian tissue or as hermaphrodites with ovarian and testicular tissue. We tested the hypothesis that the Y-linked component of this inherited sex reversal is caused by the M. d. poschiavinus Y-linked testis determining gene (symbolized Tdy or Sry) by examining gonadal development in C57BL/6J XY(POS) mice carrying a-M. musculus allele of Sry as a transgene. We found that in the presence of the transgene, XY(POS) mice developed exclusively testicular tissue. This result indicates that the Sry allele carried on the Y-POS chromosome is responsible for development of ovarian tissue in the C57BL/6J inbred strain background. We discuss this finding in light of DNA polymorphisms present in Sry alleles carried by various M. domesticus and M. musculus Y chromosomes. In addition, we present a hypothesis concerning the timing of expression of the testicular and ovarian determining genes in the developing fetal gonad based on the organization of ovarian and testicular tissue in ovotestes.
引用
收藏
页码:263 / 268
页数:6
相关论文
共 21 条
[1]  
Beamer W G, 1978, Basic Life Sci, V12, P195
[2]   MOUSE Y-CHROMOSOME [J].
BISHOP, CE .
MAMMALIAN GENOME, 1992, 3 :S289-S293
[3]  
BURGOYNE PS, 1993, GONADAL DEV FUNCTION, P373
[4]   POLYMORPHISM OF A CAG TRINUCLEOTIDE REPEAT WITHIN SRY CORRELATES WITH B6.Y-DOM SEX REVERSAL [J].
COWARD, P ;
NAGAI, K ;
CHEN, DG ;
THOMAS, HD ;
NAGAMINE, CM ;
LAU, YFC .
NATURE GENETICS, 1994, 6 (03) :245-250
[5]   SEX AND TRINUCLEOTIDE REPEATS [J].
EICHER, EM .
NATURE GENETICS, 1994, 6 (03) :221-223
[6]  
EICHER EM, 1989, GENETICS, V122, P181
[7]  
EICHER EM, 1986, ANNU REV GENET, V20, P327, DOI 10.1146/annurev.ge.20.120186.001551
[8]   MUS-POSCHIAVINUS Y-CHROMOSOME IN THE C57BL/6J MURINE GENOME CAUSES SEX REVERSAL [J].
EICHER, EM ;
WASHBURN, LL ;
WHITNEY, JB ;
MORROW, KE .
SCIENCE, 1982, 217 (4559) :535-537
[9]   A CYTOGENETIC INVESTIGATION OF INHERITED TRUE HERMAPHRODITISM IN BALB-CWT MICE [J].
EICHER, EM ;
BEAMER, WG ;
WASHBURN, LL ;
WHITTEN, WK .
CYTOGENETICS AND CELL GENETICS, 1980, 28 (1-2) :104-115
[10]   A GENE-MAPPING TO THE SEX-DETERMINING REGION OF THE MOUSE Y-CHROMOSOME IS A MEMBER OF A NOVEL FAMILY OF EMBRYONICALLY EXPRESSED GENES [J].
GUBBAY, J ;
COLLIGNON, J ;
KOOPMAN, P ;
CAPEL, B ;
ECONOMOU, A ;
MUNSTERBERG, A ;
VIVIAN, N ;
GOODFELLOW, P ;
LOVELLBADGE, R .
NATURE, 1990, 346 (6281) :245-250