POLYMORPHISM OF A CAG TRINUCLEOTIDE REPEAT WITHIN SRY CORRELATES WITH B6.Y-DOM SEX REVERSAL

被引：99

作者：

COWARD, P

NAGAI, K

CHEN, DG

THOMAS, HD

NAGAMINE, CM

LAU, YFC

机构：

[1] UNIV CALIF SAN FRANCISCO,VA MED CTR,DEPT MED,DIV CELL & DEV GENET,SAN FRANCISCO,CA 94121

[2] VANDERBILT UNIV,DEPT CELL BIOL,NASHVILLE,TN 37232

来源：

NATURE GENETICS | 1994年 / 6卷 / 03期

关键词：

D O I：

10.1038/ng0394-245

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Breeding the Y chromosome from certain Mus musculus domesticus strains onto the inbred laboratory mouse strain, C57BL/6J (B6), results in hermaphroditic progeny. This strain-dependent sex reversal suggests that there may be significant allelic variation in the murine sex determining gene, Sry. We have analysed the Sry genes from several domesticus-type Y chromosomes and show that they encode smaller proteins than the molossinus-type alleles Sry(86) and Sry(129). We have also identified a polymorphic stretch of trinucleotide repeats that is unique to strains causing sex reversal and show that specific changes in the predicted polyglutamine amino acid sequence at this site are associated with different degrees of sex reversal.

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页码：245 / 250

页数：6

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