ANALOGS OF TETRAHYDROFOLIC ACID .39(1,2). SELECTIVE BROMOACYLATION OF POLYFUNCTIONAL MOLECULES FOR SYNTHESIS OF ACTIVE-SITE-DIRECTED IRREVERSIBLE ENZYME INHIBITORS

被引：46

作者：

BAKER, BR

SANTI, DV

COWARD, JK

SHAPIRO, HS

JORDAAN, JH

机构：

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1966年 / 3卷 / 04期

关键词：

D O I：

10.1002/jhet.5570030407

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

引用

页码：425 / &

共 39 条

[1] ALKYLATION OF 2-AMINO-4-HYDROXYPYRIMIDINES WITH ACRYLONITRILE AND WITH DIMETHYL SULFATE - 2 PYRIMIDO[1,2-A]PYRIMIDINEDIONES [J].

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[2]

BAKER BH, TO BE PUBLISHED

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[4] ANALOGS OF TETRAHYDROFOLIC ACID .10. SYNTHETIC + ENZYMIC STUDIES ON CONTRIBUTION OF P-AMINOBENZOYL-L-GLUTAMATE MOIETY OF PYRIMIDYL ANALOGS TO BINDING TO SOME FOLIC COFACTOR AREA ENZYMES [J].

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[5] POTENTIAL ANTICANCER AGENTS .66. NON-CLASSICAL ANTIMETABOLITES .3. 4-(IODOACETAMIDO)-SALICYLIC ACID, AN EXO-ALKYLATING IRREVERSIBLE INHIBITOR OF GLUTAMIC DEHYDROGENASE [J].

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[6] ANALOGS OF TETRAHYDROFOLIC ACID .8. SYNTHESIS OF N-[1-(2-AMINO-4-MERCAPTO-6-METHYL-5-PYRIMIDYL)-3-PROPYL]-P-AMINOBENZOYL-L-GLUTAMIC ACID, A MERCAPTO ANALOG [J].

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[7] FACTORS IN DESIGN OF ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS [J].

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[8] ANALOGS OF TETRAHYDROFOLIC ACID .24. FURTHER OBSERVATIONS ON MODE OF PYRIMIDYL BINDING TO DIHYDROFOLIC REDUCTASE AND THYMIDYLATE SYNTHETASE BY 2-AMINO-5-(3-ANILINOPROPYL)-6-METHYL-4-PYRIMIDINOL TYPE OF INHIBITOR [J].

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[9] SYNTHESIS OF 6-SUBSTITUTED PYRIMIDINES BY WITTIG REACTION .3. VIA 2-AMINO-4-HYDROXY-5-PHENULBUTYL-6-PYRIMIDYLMETHYL TRIPHENYL PHOSPHONIUM BROMIDE [J].

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JOURNAL OF HETEROCYCLIC CHEMISTRY, 1966, 3 (03) :324-&

[10] ANALOGS OF TETRAHYDROFOLIC ACID .27. HYDROPHOBIC BONDING TO DIHYDROFOLIC REDUCTASE BY 2-AMINO-4,6-DISUBSTITUTED-5-ALKYLPYRIMIDINES AND 1-ALKYL-4,6-DIAMINO-1,2-DIHYDRO-S-TRIAZINES [J].

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