ANALOGS OF TETRAHYDROFOLIC ACID .27. HYDROPHOBIC BONDING TO DIHYDROFOLIC REDUCTASE BY 2-AMINO-4,6-DISUBSTITUTED-5-ALKYLPYRIMIDINES AND 1-ALKYL-4,6-DIAMINO-1,2-DIHYDRO-S-TRIAZINES

被引：68

作者：

BAKER, BR

HO, BT

SANTI, DV

机构：

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1965年 / 54卷 / 10期

关键词：

D O I：

10.1002/jps.2600541005

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

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页码：1415 / &

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[1] ANALOGS OF TETRAHYDROFOLIC ACID .7. SYNTHESIS OF N-[1-(2-AMINO-4-HYDROXY-6-METHYL-5-PYRIMIDYL)-3-PROPYL]-P-AMINOBENZOYL-L-GLUTAMIC ACID, AN INHIBITOR OF FOLIC REDUCTASE [J].

BAKER, BR ;

MORREAL, CE .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1963, 52 (09) :840-&

[2] ANALOGS OF TETRAHYDROFOLIC ACID .10. SYNTHETIC + ENZYMIC STUDIES ON CONTRIBUTION OF P-AMINOBENZOYL-L-GLUTAMATE MOIETY OF PYRIMIDYL ANALOGS TO BINDING TO SOME FOLIC COFACTOR AREA ENZYMES [J].

BAKER, BR ;

SANTI, DV ;

ALMAULA, PI ;

WERKHEISER, WC .

JOURNAL OF MEDICINAL CHEMISTRY, 1964, 7 (01) :24-&

[3] FACTORS IN DESIGN OF ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS [J].

BAKER, BR .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1964, 53 (04) :347-&

[4] ANALOGS OF TETRAHYDROFOLIC ACID .24. FURTHER OBSERVATIONS ON MODE OF PYRIMIDYL BINDING TO DIHYDROFOLIC REDUCTASE AND THYMIDYLATE SYNTHETASE BY 2-AMINO-5-(3-ANILINOPROPYL)-6-METHYL-4-PYRIMIDINOL TYPE OF INHIBITOR [J].

BAKER, BR ;

SANTI, DV .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1965, 54 (09) :1252-&

[5] ANALOGS OF TETRAHYDROFOLIC ACID .26. SYNTHESIS OF SOME 5-ARYL AND 5-ARALKYL PYRIMIDINE-6-CARBOXYLIC ACIDS AND THEIR EFFECT ON DIHYDROFOLIC REDUCTASE AND THYMIDYLATE SYNTHETASE [J].

BAKER, BR ;

JORDAAN, JH .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1965, 2 (02) :162-&

[6] ANALOGS OF TETRAHYDROFOLIC ACID .9. SYNTHESIS OF N-[1-(2-AMINO-4-HYDROXY-6-PHENYL-5-PYRIMIDYL)-3-PROPYL]-P-AMINOBENZOYL-L-GLUTAMIC ACID, A NONCLASSICAL INHIBITOR OF SOME FOLIC COFACTOR AREA ENZYMES [J].

BAKER, BR ;

SHAPIRO, HS .

JOURNAL OF MEDICINAL CHEMISTRY, 1963, 6 (06) :664-&

[7] ANALOGS OF TETRAHYDROFOLIC ACID .23. 1-(OMEGA-PHENYLALKYL)-4,6-DIAMINO-1,2-DIHYDRO-S-TRIAZINES AS INHIBITORS OF DIHYDROFOLIC REDUCTASE [J].

BAKER, BR ;

HO, BT .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1965, 2 (01) :72-&

[8] ANALOGS OF TETRAHYDROFOLIC ACID .25. 2,4-DIAMINO-6-PHENETHYLPTERIDINE AN INHIBITOR OF DIHYDROFOLIC REDUCTASE [J].

BAKER, BR ;

HO, BT .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1965, 54 (09) :1261-&

[9] ANALOGS OF TETRAHYDROFOLIC ACID .22. EFFECTS OF MODIFICATION OF BRIDGE BETWEEN PYRIMIDYL AND PHENYL MOIETIES OF 2-AMINO-5-(3-ANILINOPROPYL)-6-METHYL-4-PYRIMIDINOL ON INHIBITION OF DIHYDROFOLIC REDUCTASE AND THYMIDYLATE SYNTHETASE 3 [J].

BAKER, BR ;

COWARD, JK .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1965, 54 (05) :714-&

[10] ANALOGS OF TETRAHYDROFOLIC ACID .18. ON MODE OF BINDING OF SOME 6-ARYL- AND 6-ARALKYLPYRIMIDINES TO FOLIC REDUCTASE [J].

BAKER, BR ;

SHAPIRO, HS ;

WERKHEISER, WC .

JOURNAL OF MEDICINAL CHEMISTRY, 1965, 8 (03) :283-+

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