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SEX DETERMINATION AND DOSAGE COMPENSATION - LESSONS FROM FLIES AND WORMS

被引：107
作者：
PARKHURST, SM
MENEELY, PM
机构：
[1] Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle
来源：
SCIENCE | 1994年 / 264卷 / 5161期
关键词：
D O I：
10.1126/science.8178152
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
In both Drosophila melanogaster and Caenorhabditis elegans somatic sex determination, germline sex determination, and dosage compensation are controlled by means of a chromosomal signal known as the X:A ratio. A variety of mechanisms are used for establishing and implementing the chromosomal signal, and these do not appear to be similar in the two species. Instead, the study of sex determination and dosage compensation is providing more general lessons about different types of signaling pathways used to control alternative developmental states of cells and organisms.
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页码：924 / 932
页数：9
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