Mammalian X-chromosome inactivation and the XIST gene

被引：81

作者：

Ballabio, Andrea ^{[1
]}

Willard, Huntington F. ^{[2
]}

机构：

[1] Baylor Coll Med, Inst Mol Genet, 1 Baylor Plaza, Houston, TX 77030 USA

[2] Stanford Univ, Dept Genet, Sch Med, Stanford, CA 94305 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1992年 / 2卷 / 03期

关键词：

D O I：

10.1016/S0959-437X(05)80155-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

X-chromosome inactivation is a unique developmental event that results in the cis-limited transcriptional inactivation of most genes on one of the two X chromosomes in female mammals. Studies in both human and mouse have demonstrated that X inactivation requires the presence in cis of a locus, the X-inactivation center, that is thought to be involved in the initiation and/or spreading of the inactivation signal in early development. Identification and characterization of a gene, XIST, which is located at or near the X-inactivation center and which is expressed specifically from the inactive X chromosome in both humans and mouse, suggests that it may be involved in X inactivation.

引用

页码：439 / 447

页数：9

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