INSECT DEFENSINS - INDUCIBLE ANTIBACTERIAL PEPTIDES

被引：255

作者：

HOFFMANN, JA

HETRU, C

机构：

[1] Jules Hoffmann and Charles Hetru are at the Laboratoire de Biologie Générale of the Université Louis Pasteur, CNRS Research Unit 1490, Molecular and Cellular Insect Immunity, 12 rue de l'Université

来源：

IMMUNOLOGY TODAY | 1992年 / 13卷 / 10期

关键词：

D O I：

10.1016/0167-5699(92)90092-L

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In response to bacterial challenge or trauma, insects produce a battery of bactericidal or bacteriostatic molecules with a broad spectrum of activity against Gram-positive and/or Gram-negative bacteria; most are small-sized cationic peptides. This review focuses on insect defensins, a large group of inducible antibacterial peptides that are present both in ancient and recent insect orders. This immune response of insects shares many of the characteristics of the mammalian acute phase response.

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页码：411 / 415

页数：5

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