ADMINISTRATION OF ANTIGRANULOCYTE MONOCLONAL-ANTIBODY RB6-8C5 PREVENTS EXPRESSION OF ACQUIRED-RESISTANCE TO LISTERIA-MONOCYTOGENES INFECTION IN PREVIOUSLY IMMUNIZED MICE

被引：61

作者：

CZUPRYNSKI, CJ ^{[1
]}

BROWN, JF ^{[1
]}

WAGNER, RD ^{[1
]}

STEINBERG, H ^{[1
]}

机构：

[1] UNIV WISCONSIN,SCH VET MED,DEPT PATHOBIOL SCI,MADISON,WI 53706

来源：

INFECTION AND IMMUNITY | 1994年 / 62卷 / 11期

关键词：

D O I：

10.1128/IAI.62.11.5161-5163.1994

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent studies have established the importance of neutrophils in innate resistance to Listeria monocytogenes infection in mice, The purpose of this study was to determine the importance of neutrophils in acquired resistance to L. monocytogenes infection. Previously immunized mice that were depleted of neutrophils by administration of the antigranulocyte monoclonal antibody RB6-8C5 demonstrated less resistance to L. monocytogenes challenge than did nonimmunized control mice. In contrast, immunized control mice exhibited a heightened resistance to rechallenge, as expected. These results suggest that neutrophils make previously unrecognized contributions to acquired immunity to a facultative intracellular pathogen.

引用

页码：5161 / 5163

页数：3

共 26 条

[11]

FLEMING TJ, 1993, J IMMUNOL, V151, P2399

[12]

GERVAIS F, 1984, J IMMUNOL, V132, P2078

[13] EFFECTOR FUNCTION OF HEPATOCYTES AND KUPFFER CELLS IN THE RESOLUTION OF SYSTEMIC BACTERIAL-INFECTIONS [J].

GREGORY, SH ;

BARCZYNSKI, LK ;

WING, EJ .

JOURNAL OF LEUKOCYTE BIOLOGY, 1992, 51 (04) :421-424

[14]

HAVELL EA, 1989, J IMMUNOL, V143, P2894

[15]

HESTDAL K, 1991, J IMMUNOL, V147, P22

[16] EARLY EXPRESSION OF CYTOKINE MESSENGER-RNA IN MICE INFECTED WITH LISTERIA-MONOCYTOGENES [J].

IIZAWA, Y ;

BROWN, JF ;

CZUPRYNSKI, CJ .

INFECTION AND IMMUNITY, 1992, 60 (10) :4068-4073

[17] RESISTANCE OF SCID MICE TO CANDIDA-ALBICANS ADMINISTERED INTRAVENOUSLY OR COLONIZING THE GUT - ROLE OF POLYMORPHONUCLEAR LEUKOCYTES AND MACROPHAGES [J].

JENSEN, J ;

WARNER, T ;

BALISH, E .

JOURNAL OF INFECTIOUS DISEASES, 1993, 167 (04) :912-919

[18]

KAUFMANN SHE, 1993, ANNU REV IMMUNOL, V11, P129, DOI 10.1146/annurev.iy.11.040193.001021

[19] POLYS LAMENT - THE NEGLECTED ROLE OF THE POLYMORPHONUCLEAR NEUTROPHIL IN THE AFFERENT LIMB OF THE IMMUNE-RESPONSE [J].

LLOYD, AR ;

OPPENHEIM, JJ .

IMMUNOLOGY TODAY, 1992, 13 (05) :169-172

[20] DIFFERENT ROLES OF ALPHA-BETA AND GAMMA-DELTA T-CELLS IN IMMUNITY AGAINST AN INTRACELLULAR BACTERIAL PATHOGEN [J].

MOMBAERTS, P ;

ARNOLDI, J ;

RUSS, F ;

TONEGAWA, S ;

KAUFMANN, SHE .

NATURE, 1993, 365 (6441) :53-56

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