GENETIC DISSECTION OF COMPLEX TRAITS - GUIDELINES FOR INTERPRETING AND REPORTING LINKAGE RESULTS

被引:4364
作者
LANDER, E [1 ]
KRUGLYAK, L [1 ]
机构
[1] MIT,DEPT BIOL,CAMBRIDGE,MA 02139
关键词
D O I
10.1038/ng1195-241
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Genetic studies are under way for many complex traits, spurred by the recent feasibility of whole genome scans. Clear guidelines for the interpretation of linkage results are needed to avoid a flood of false positive claims. At the same time, an overly cautious approach runs the risk of causing true hints of linkage to be missed. We address this problem by proposing specific standards designed to maintain rigor while also promoting communication.
引用
收藏
页码:241 / 247
页数:7
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