A GENOME-WIDE SEARCH FOR HUMAN TYPE-1 DIABETES SUSCEPTIBILITY GENES

被引：1194

作者：

DAVIES, JL

KAWAGUCHI, Y

BENNETT, ST

COPEMAN, JB

CORDELL, HJ

PRITCHARD, LE

REED, PW

GOUGH, SCL

JENKINS, SC

PALMER, SM

BALFOUR, KM

ROWE, BR

FARRALL, M

BARNETT, AH

BAIN, SC

TODD, JA

机构：

[1] UNIV OXFORD,WELLCOME TRUST CTR HUMAN GENET,OXFORD OX3 7BN,ENGLAND

[2] UNIV BIRMINGHAM,BIRMINGHAM HEARTLANDS HOSP,DEPT MED DIABET ENDOCRINOL,BIRMINGHAM B9 5SS,W MIDLANDS,ENGLAND

[3] HAMMERSMITH HOSP,MRC,CLIN RES CTR,LONDON W12 0NN,ENGLAND

来源：

NATURE | 1994年 / 371卷 / 6493期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/371130a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have searched the human genome for genes that predispose to type 1 (insulin-dependent) diabetes mellitus using semi-automated fluorescence-based technology and linkage analysis. In addition to IDDM1 (in the major histocompatibility complex on chromosome 6p21) and IDDM2 (in the insulin gene region on chromosome 11p15), eighteen different chromosome regions showed some positive evidence of linkage to disease. Linkages to chromosomes iio (IDDM4) and 6q (IDDM5) were confirmed by replication, and chromosome is may encode a fifth disease locus. There are probably no genes with large effects aside from IDDM1. Therefore polygenic inheritance Is indicated, with a major locus at the major histocompatibility complex.

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页码：130 / 136

页数：7

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[4] A POLYMORPHIC LOCUS NEAR THE HUMAN INSULIN GENE IS ASSOCIATED WITH INSULIN-DEPENDENT DIABETES-MELLITUS [J].

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[9] TYPE-1 DIABETES IN MICE IS LINKED TO THE INTERLEUKIN-1 RECEPTOR AND LSH/ITY/BCG GENES ON CHROMOSOME-1 [J].

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PRESSEY, A ;

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[10] NO EVIDENCE FOR LINKAGE BETWEEN DIABETES AND THE KIDD MARKER [J].

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