DIMINISHED SUPPORT FOR LINKAGE BETWEEN MANIC-DEPRESSIVE ILLNESS AND X-CHROMOSOME MARKERS IN 3 ISRAELI PEDIGREES

被引：154

作者：

BARON, M

FREIMER, NF

RISCH, N

LERER, B

ALEXANDER, JR

STRAUB, RE

ASOKAN, S

DAS, K

PETERSON, A

AMOS, J

ENDICOTT, J

OTT, J

GILLIAM, TC

机构：

[1] COLUMBIA UNIV COLL PHYS & SURG,DEPT PSYCHIAT,NEW YORK,NY 10032

[2] COLUMBIA UNIV COLL PHYS & SURG,DEPT GENET & DEV,NEW YORK,NY 10032

[3] YALE UNIV,SCH MED,DEPT EPIDEMIOL & PUBL HLTH,NEW HAVEN,CT 06510

[4] YALE UNIV,SCH MED,DEPT GENET,NEW HAVEN,CT 06510

[5] HEBREW UNIV JERUSALEM,HADASSAH MED CTR,DEPT PSYCHIAT,IL-91120 JERUSALEM,ISRAEL

[6] BOSTON UNIV,MED CTR,CTR HUMAN GENET,BOSTON,MA 02118

来源：

NATURE GENETICS | 1993年 / 3卷 / 01期

关键词：

D O I：

10.1038/ng0193-49

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The hypothesis that chromosomal region Xq27-28 harbours a gene for manic-depression has been a focus of interest in human genetics. X-linked inheritance of manic depressive illness has been re-examined in 3 multigeneration Israeli kindreds. Extension and re-evaluation of pedigree data, including new individuals, diagnostic follow-up, and analysis with DNA markers, shows greatly diminished support for linkage to Xq28. The peak lod scores in two of the pedigrees have dropped several lod units to clearly negative values at the RCP-F8-G6PD gene cluster. On the other hand, positive lod scores (Z(max) = 2.09) are sustained in another pedigree at the same map location. None of the pedigrees show linkage to more proximal markers, including the Xq27 locus DXS98. Our analysis underscores the uncertainties in studying complex disorders.

引用

页码：49 / 55

页数：7

共 39 条

[1]

ANDERSON MA, 1984, IN VITRO CELL DEV B, V20, P856

[2]

ANDREASEN NC, 1977, ARCH GEN PSYCHIAT, V34, P1229

[3] GENETIC-LINKAGE BETWEEN X-CHROMOSOME MARKERS AND BIPOLAR AFFECTIVE-ILLNESS [J].