CHARACTERIZATION AND MAPPING OF THE HUMAN SOX4 GENE

被引：59

作者：

FARR, CJ

EASTY, DJ

RAGOUSSIS, J

COLLIGNON, J

LOVELLBADGE, R

GOODFELLOW, PN

机构：

[1] UMDS, GUYS HOSP, DIV MED & MOLEC GENET, LONDON SE1 9RT, ENGLAND

[2] ST GEORGES MED SCH, DEPT ANAT, LONDON SW17 ORE, ENGLAND

[3] NATL INST MED RES, MRC, EUKARYOT MOLEC GENET LAB, LONDON NW7 1AA, ENGLAND

来源：

MAMMALIAN GENOME | 1993年 / 4卷 / 10期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1007/BF00361388

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The SOX genes comprise a large family related by homology to the HMG-box region of the testis-determining gene SRY. We have cloned and sequenced the human SOX4 gene. The open reading frame encodes a 474 amino acid protein, which includes an HMG-box. The non-box sequence is particularly rich in serine residues and has several polyglycine and polyalanine stretches. With somatic cell hybrids, human SOX4 has been mapped to Chromosome (Chr) 6p distal to the MHC region. There is no evidence for clustering of other members of the SOX1, -2, and -3 or SOX4 gene families around the SOX4 locus.

引用

页码：577 / 584

页数：8

共 39 条

[1]

ALEXANDERBRIDGES M, 1992, ADV ENZYME REGUL, V32, P149

[2] IDENTIFICATION OF A CORE MOTIF THAT IS RECOGNIZED BY 3 MEMBERS OF THE HMG CLASS OF TRANSCRIPTIONAL REGULATORS - IRE-ABP, SRY, AND TCF-1-ALPHA [J].