cRGD-functionalized polymer micelles for targeted doxorubicin delivery

被引：348

作者：

Nasongkla, N ^{[1
]}

Shuai, X ^{[1
]}

Ai, H ^{[1
]}

Weinberg, BD ^{[1
]}

Pink, J ^{[1
]}

Boothman, DA ^{[1
]}

Gao, JM ^{[1
]}

机构：

[1] Case Western Reserve Univ, Dept Radiat Oncol, Cleveland, OH 44106 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 46期

关键词：

antitumor agents; bioorganic chemistry; drug delivery; micelles; peptides;

D O I：

10.1002/anie.200460800

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Targeting micelles: Cyclic pentapeptide cRGDfk (red triangles), which targets integrin αvβ3, was conjugated to the outer shell of doxorubicin-loaded (red hexagons) polymeric micelles by using a postmicelle modification method. The modified micelles significantly enhanced their internalization (up to 30-fold) by receptor-mediated endocytosis in tumor endothelial cells overexpressing the αvβ3 receptor. (Figure presented).

引用

页码：6323 / 6327

页数：5

共 32 条

[1] Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model [J].

Arap, W ;

Pasqualini, R ;

Ruoslahti, E .

SCIENCE, 1998, 279 (5349) :377-380

[2] Design of environment-sensitive supramolecular assemblies for intracellular drug delivery: Polymeric micelles that are responsive to intracellular pH change [J].

Bae, Y ;

Fukushima, S ;

Harada, A ;

Kataoka, K .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, 42 (38) :4640-4643

[3]

Bae Y., 2003, ANGEW CHEM, V115, P4788, DOI DOI 10.1002/ange.200250653

[4] INTEGRIN ALPHA(V)BETA(3) ANTAGONISTS PROMOTE TUMOR-REGRESSION BY INDUCING APOPTOSIS OF ANGIOGENIC BLOOD-VESSELS [J].

BROOKS, PC ;

MONTGOMERY, AMP ;

ROSENFELD, M ;

REISFELD, RA ;

HU, TH ;

KLIER, G ;

CHERESH, DA .

CELL, 1994, 79 (07) :1157-1164

[5] DIRECT MEASUREMENT OF COLLOIDAL FORCES USING AN ATOMIC FORCE MICROSCOPE [J].

DUCKER, WA ;

SENDEN, TJ ;

PASHLEY, RM .

NATURE, 1991, 353 (6341) :239-241

[6] Adhesion events in angiogenesis [J].

Eliceiri, BP ;

Cheresh, DA .

CURRENT OPINION IN CELL BIOLOGY, 2001, 13 (05) :563-568

[7] N-succinyl-(β-alanyl-L-leucyl-L-alanyl-L-leucyl)doxorubicin:: An extracellularly tumor-activated prodrug devoid of intravenous acute toxicity [J].

Fernandez, AM ;

Van Derpoorten, K ;

Dasnois, L ;

Lebtahi, K ;

Dubois, V ;

Lobl, TJ ;

Gangwar, S ;

Oliyai, C ;

Lewis, ER ;

Shochat, D ;

Trouet, A .

JOURNAL OF MEDICINAL CHEMISTRY, 2001, 44 (22) :3750-3753

[8] Macromolecular therapeutics - Advantages and prospects with special emphasis on solid tumour targeting [J].

Greish, K ;

Fang, J ;

Inutsuka, T ;

Nagamitsu, A ;

Maeda, H .

CLINICAL PHARMACOKINETICS, 2003, 42 (13) :1089-1105

[9] Supramolecular drug-delivery systems based on polymeric core-shell architectures [J].

Haag, R .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2004, 43 (03) :278-282

[10]

Haag R., 2004, ANGEW CHEM, V116, P280

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