Design of environment-sensitive supramolecular assemblies for intracellular drug delivery: Polymeric micelles that are responsive to intracellular pH change

被引：1162

作者：

Bae, Y ^{[1
]}

Fukushima, S ^{[1
]}

Harada, A ^{[1
]}

Kataoka, K ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Engn, Dept Mat Sci & Engn, Bunkyo Ku, Tokyo 1138656, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 38期

关键词：

anticancer agents; micelles; polymers; self-assembly; supramolecular chemistry;

D O I：

10.1002/anie.200250653

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Drug smuggling: Micelles made up of block copolymers and the anticancer drug adriamycin (ADR), which is linked to the polymer by a pH-sensitive linker, have been prepared (see picture). Treatment of cancer cells with the micelles shows that the micelles are transported into the cell by endocytosis, thus bypassing the cell-membrane transporters. In the cell, the decrease in pH value triggers the release of the ADR, which retains its cytotoxic effect. The released ADR fluoresces which allows its localization within the cells to be detected.

引用

页码：4640 / 4643

页数：4

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