Supramolecular drug-delivery systems based on polymeric core-shell architectures

被引：549

作者：

Haag, R ^{[1
]}

机构：

[1] Univ Dortmund, D-4427 Dortmund, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 03期

关键词：

block copolymers; dendrimers; drug delivery; micelles; supramolecular chemistry;

D O I：

10.1002/anie.200301694

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Hitting the target: Although the cellular uptake of supramolecular nanocarriers by endocytosis is not cell-specific, a high passive selectivity has been observed in porous tissues, such as tumor tissue. The encapsulated, often toxic, drug is efficiently shielded and can develop its activity by selective release from the nanocarrier upon a shift of the pH value in the tumor tissue or inside the cell (see scheme).

引用

页码：278 / 282

页数：5

共 62 条

[1]

Allen C, 2000, DRUG DELIV, V7, P139

[2]

Baars MWPL, 2000, TOP CURR CHEM, V210, P131

[3] Design of environment-sensitive supramolecular assemblies for intracellular drug delivery: Polymeric micelles that are responsive to intracellular pH change [J].