The dawning era of polymer therapeutics

被引：2711

作者：

Duncan, R ^{[1
]}

机构：

[1] Cardiff Univ, Welsh Sch Pharm, Ctr Polymer Therapeut, Cardiff CF10 3XF, S Glam, Wales

来源：

NATURE REVIEWS DRUG DISCOVERY | 2003年 / 2卷 / 05期

关键词：

D O I：

10.1038/nrd1088

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

As we enter the twenty-first century, research at the interface of polymer chemistry and the biomedical sciences has given rise to the first nano-sized (5-100 nm) polymer-based pharmaceuticals, the 'polymer therapeutics'. Polymer therapeutics include rationally designed macromolecular drugs, polymer-drug and polymer-protein conjugates, polymeric micelles containing covalently bound drug, and polyplexes for DNA delivery. The successful clinical application of polymer-protein conjugates, and promising clinical results arising from trials with polymer-anticancer-drug conjugates, bode well for the future design and development of the ever more sophisticated bio-nanotechnologies that are needed to realize the full potential of the post-genomic age.

引用

页码：347 / 360

页数：14

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