Molecular mechanisms of cancer pain

被引：341

作者：

Mantyh, PW

Clohisy, DR

Koltzenburg, M

Hunt, SP

机构：

[1] Univ Minnesota, Dept Prevent Sci, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Dept Psychiat & Neurosci, Minneapolis, MN 55455 USA

[3] Univ Minnesota, Med Sch, Dept Orthopaed Surg, Minneapolis, MN 55455 USA

[4] Univ Minnesota, Ctr Canc, Minneapolis, MN 55455 USA

[5] Univ London, Inst Child Hlth, London WC1N 1EH, England

[6] Univ London, Neurol Inst, London WC1N 1EH, England

[7] Natl Hosp Neurol & Neurosurg, London WC1N 1EH, England

[8] UCL, Dept Anat & Dev Biol, London WC1N 1EH, England

来源：

NATURE REVIEWS CANCER | 2002年 / 2卷 / 03期

关键词：

D O I：

10.1038/nrc747

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pain is the most disruptive influence on the quality of life of cancer patients. Although significant advances are being made in cancer treatment and diagnosis, the basic neurobiology of cancer pain is poorly understood. New insights into these mechanisms are now arising from animal models, and have the potential to fundamentally change the way that cancer pain is controlled.

引用

页码：201 / 209

页数：9

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[1] Differential contribution of the two phases of the formalin test to the pattern of c-fos expression in the rat spinal cord: Studies with remifentanil and lidocaine [J].