Molecular mechanisms of cancer pain

被引：341

作者：

Mantyh, PW

Clohisy, DR

Koltzenburg, M

Hunt, SP

机构：

[1] Univ Minnesota, Dept Prevent Sci, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Dept Psychiat & Neurosci, Minneapolis, MN 55455 USA

[3] Univ Minnesota, Med Sch, Dept Orthopaed Surg, Minneapolis, MN 55455 USA

[4] Univ Minnesota, Ctr Canc, Minneapolis, MN 55455 USA

[5] Univ London, Inst Child Hlth, London WC1N 1EH, England

[6] Univ London, Neurol Inst, London WC1N 1EH, England

[7] Natl Hosp Neurol & Neurosurg, London WC1N 1EH, England

[8] UCL, Dept Anat & Dev Biol, London WC1N 1EH, England

来源：

NATURE REVIEWS CANCER | 2002年 / 2卷 / 03期

关键词：

D O I：

10.1038/nrc747

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pain is the most disruptive influence on the quality of life of cancer patients. Although significant advances are being made in cancer treatment and diagnosis, the basic neurobiology of cancer pain is poorly understood. New insights into these mechanisms are now arising from animal models, and have the potential to fundamentally change the way that cancer pain is controlled.

引用

收藏

页码：201 / 209

页数：9

相关论文

共 127 条

[21] Endothelin-1 and metastatic cancer pain [J].

Davar, G .

PAIN MEDICINE, 2001, 2 (01) :24-27

[22]

Dawas K, 1999, ANN ROY COLL SURG, V81, P306

[23] The Amsterdam Pain Management Index compared to eight frequently used outcome measures to evaluate the adequacy of pain treatment in cancer patients with chronic pain [J].

de Wit, R ;

van Dam, F ;

Loonstra, S ;

Zandbelt, L ;

van Buuren, A ;

van der Heijden, K ;

Leenhouts, G ;

Abu-Saad, HH .

PAIN, 2001, 91 (03) :339-349

[24]

Delaisse Jean-Marie, 1992, P289

[25] The role of neuroinflammation and neuroimmune activation in persistent pain [J].

DeLeo, JA ;

Yezierski, RP .

PAIN, 2001, 90 (1-2) :1-6

[26] Association of somatic action potential shape with sensory receptive properties in guinea-pig dorsal root ganglion neurones [J].

Djouhri, L ;

Bleazard, L ;

Lawson, SN .

JOURNAL OF PHYSIOLOGY-LONDON, 1998, 513 (03) :857-872

[27] Substance P receptor (neurokinin-1)-expressing neurons in lamina I of the spinal cord encode for the intensity of noxious stimulation: A c-Fos study in rat [J].

Doyle, CA ;

Hunt, SP .

NEUROSCIENCE, 1999, 89 (01) :17-28

[28] ACTIVITY-DEPENDENT NEURONAL PLASTICITY FOLLOWING TISSUE-INJURY AND INFLAMMATION [J].

DUBNER, R ;

RUDA, MA .

TRENDS IN NEUROSCIENCES, 1992, 15 (03) :96-103

[29] Increased cyclooxygenase-2 levels in carcinogen-induced rat colonic tumors [J].

DuBois, RN ;

Radhika, A ;

Reddy, BS ;

Entingh, AJ .

GASTROENTEROLOGY, 1996, 110 (04) :1259-1262

[30] Biochemistry of cyclooxygenase (COX)-2 inhibitors and molecular pathology of COX-2 in neoplasia [J].

Fosslien, E .

CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES, 2000, 37 (05) :431-502

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