Endothelin-1 and tumour development

被引：30

作者：

Asham, EH ^{[1
]}

Loizidou, M ^{[1
]}

Taylor, I ^{[1
]}

机构：

[1] UCL, Dept Surg, London, England

来源：

EUROPEAN JOURNAL OF SURGICAL ONCOLOGY | 1998年 / 24卷 / 01期

关键词：

endothelin; endothelial cells; angiogenesis; tumour growth;

D O I：

10.1016/S0748-7983(98)80128-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

There has been a growing conviction amongst oncologists that cancer is a disease characterized by changes in specific molecules. These changes include alteration in the structure, regulation or quantity of growth factors and their receptors, signal transducers and the proteins encoded by dominant or suppressor/recessive oncogenes. The role of endothelin (vasoactive peptide) in tumour cell signal transduction and mitogenesis and induction of endothelial cell growth and angiogenesis in tumour growth is discussed in this article.

引用

页码：57 / 59

页数：3

共 24 条

[1]

ARAI H, 1993, J BIOL CHEM, V268, P3463

[2] SPLANCHNIC BLOOD-FLOW CHANGES IN THE PRESENCE OF HEPATIC TUMOR - EVIDENCE OF A HUMORAL MEDIATOR [J].