CCR5 provides a signal for microbial induced production of IL-12 by CD8α+ dendritic cells

被引：288

作者：

Aliberti, J

Sousa, CRE

Schito, M

Hieny, S

Wells, T

Huffnagle, GB

Sher, A

机构：

[1] NIAID, Immunobiol Sect, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA

[2] Ares Serono Pharmaceut Res Inst SA, Geneva, Switzerland

[3] Imperial Canc Res Fund, Immunobiol Lab, London WC2A 3PX, England

[4] Univ Michigan, Med Ctr, Dept Pulm Med, Ann Arbor, MI USA

[5] Univ Michigan, Med Ctr, Dept Immunol Microbiol, Ann Arbor, MI USA

来源：

NATURE IMMUNOLOGY | 2000年 / 1卷 / 01期

关键词：

D O I：

10.1038/76957

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The activation of dendritic cells (DC) to produce interleukin 12 (IL-12) is thought to be a key step in the initiation of cell-mediated immunity to intracellular pathogens. Here we show that ligation of the C-C chemokine receptor (CCR) 5 can provide a major signal for the induction of IL-12 synthesis by the CD8 alpha(+) subset of DC and that this pathway is important in establishing interferon gamma-dependent resistance to the protozoan parasite Toxoplasma gondii. These findings support the concept that the early induction of chemokines by invading pathogens is a critical step not only for the recruitment of DC but also for the determination of their subsequent immunologic function.

引用

页码：83 / 87

页数：5

共 26 条

[21] The role of dendritic cells in the induction and regulation of immunity to microbial infection [J].