The role of CD4+ T helper cells in the cytotoxic T lymphocyte response to HIV-1

被引：125

作者：

Altfeld, M

Rosenberg, ES

机构：

[1] Massachusetts Gen Hosp, Partners AIDS Res Ctr, Charlestown, MA 02114 USA

[2] Harvard Univ, Sch Med, Charlestown, MA 02114 USA

[3] Massachusetts Gen Hosp, Infect Dis Unit, Boston, MA 02114 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2000年 / 12卷 / 04期

关键词：

D O I：

10.1016/S0952-7915(00)00103-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Virus-specific CD4(+) T cell help and CD8(+) cytotoxic T cell (CTL) responses are critical for the maintenance of effective immunity in chronic viral infections. HIV-1 infection presents a unique situation in which HIV-l-specific T helper cell responses are characteristically impaired and virus-specific CTLs wane over time as disease progresses; a relationship exists between T cell help and Cn responses in HIV-1 infection.

引用

收藏

页码：375 / 380

页数：6

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