POSSIBLE MECHANISM INVOLVING T-LYMPHOCYTE RESPONSE TO NONSTRUCTURAL PROTEIN-3 IN VIRAL CLEARANCE IN ACUTE HEPATITIS-C VIRUS-INFECTION

被引：630

作者：

DIEPOLDER, HM

ZACHOVAL, R

HOFFMANN, RM

WIERENGA, EA

SANTANTONIO, T

JUNG, MC

EICHENLAUB, D

PAPE, GR

机构：

[1] UNIV MUNICH,KLINIKUM GROSSHADERN,DEPT MED 2,D-81377 MUNICH,GERMANY

[2] UNIV AMSTERDAM,CELL BIOL & HISTOL LAB,1105 AZ AMSTERDAM,NETHERLANDS

[3] UNIV BARI,MALATTIE INFETT CLIN,BARI,ITALY

[4] HOSP SCHWABING,DEPT INTERNAL MED 4,MUNICH,GERMANY

来源：

LANCET | 1995年 / 346卷 / 8981期

关键词：

D O I：

10.1016/S0140-6736(95)91691-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In acute hepatitis C virus (HCV) infection only 20-50% of patients spontaneously clear the virus. To characterise the immune reaction during that phase we studied the response of peripheral blood mononuclear cells (PBMC) to the recombinant HCV proteins core, non-structural protein 3 (NS3), NS4, and NS5 in 14 patients with acute hepatitis C. All eight patients with self-limited disease compared with two of six with evolving chronic infection showed an NS3- specific PBMC response (p=0.015). Of 65 patients with established chronic hepatitis C, five showed a PBMC response to NS3. NS3-specific CD4 T-cell clones from patients with self-limited infection predominantly produced interferon-gamma and may thus support cytotoxic effector mechanisms important for viral clearance.

引用

收藏

页码：1006 / 1007

页数：2

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