Receptor recognition by gp130 cytokines

被引：168

作者：

Bravo, J

Heath, JK ^{[1
]}

机构：

[1] Univ Birmingham, CRC, Growth Factor Grp, Sch Biosci, Birmingham B15 2TT, W Midlands, England

[2] MRC, Mol Biol Lab, Cambridge CB2 2QH, England

来源：

EMBO JOURNAL | 2000年 / 19卷 / 11期

关键词：

cytokines; gp130; receptor recognition epitopes; receptor signalling complexes;

D O I：

10.1093/emboj/19.11.2399

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cytokines of the gp130 family exert their diverse biological effects by formation of stable high affinity transmembrane receptor complexes that are characterized by the presence of the shared transmembrane signalling receptor gp130. Different gp130 ligands form signalling complexes that vary in both composition and stoichiometry. Analysis of the three-dimensional structure of selected ligands and receptor elements indicates that ligands display three topologically conserved receptor recognition epitopes that interact with complementary ligand recognition elements. The composition of the signalling complex and downstream biological responses is defined by the relative affinity of different receptor components for these epitopes. The detailed structure of receptor recognition epitopes indicates that the generation of small molecule cytokine mimetics may be a feasible objective.

引用

收藏

页码：2399 / 2411

页数：13

相关论文

共 119 条

[91] Interleukin-6: Structure-function relationships [J].

Simpson, RJ ;

Hammacher, A ;

Smith, DK ;

Matthews, JM ;

Ward, LD .

PROTEIN SCIENCE, 1997, 6 (05) :929-955

[92] 1.9 angstrom crystal structure of interleukin 6: Implications for a novel mode of receptor dimerization and signaling [J].

Somers, W ;

Stahl, M ;

Seehra, JS .

EMBO JOURNAL, 1997, 16 (05) :989-997

[93] CYTOKINE STRUCTURAL TAXONOMY AND MECHANISMS OF RECEPTOR ENGAGEMENT [J].

SPRANG, SR ;

BAZAN, JF .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 1993, 3 (06) :815-827

[94] Cloning and characterization of a novel class I cytokine receptor [J].

Sprecher, CA ;

Grant, FJ ;

Baumgartner, JW ;

Presnell, SR ;

Schrader, SK ;

Yamagiwa, T ;

Whitmore, TE ;

O'Hara, PJ ;

Foster, DF .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1998, 246 (01) :82-90

[95] The interactions of the cytokine-binding homology region and immunoglobulin-like domains of gp130 with oncostatin M: implications for receptor complex formation [J].

Staunton, D ;

Hudson, KR ;

Heath, JK .

PROTEIN ENGINEERING, 1998, 11 (11) :1093-1102

[96] BLASTOCYST IMPLANTATION DEPENDS ON MATERNAL EXPRESSION OF LEUKEMIA INHIBITORY FACTOR [J].

STEWART, CL ;

KASPAR, P ;

BRUNET, LJ ;

BHATT, H ;

GADI, I ;

KONTGEN, F ;

ABBONDANZO, SJ .

NATURE, 1992, 359 (6390) :76-79

[97] MOLECULAR-CLONING, EXPRESSION AND REGIONAL DISTRIBUTION OF RAT CILIARY NEUROTROPHIC FACTOR [J].

STOCKLI, KA ;

LOTTSPEICH, F ;

SENDTNER, M ;

MASIAKOWSKI, P ;

CARROLL, P ;

GOTZ, R ;

LINDHOLM, D ;

THOENEN, H .

NATURE, 1989, 342 (6252) :920-923

[98] Efficiency of signalling through cytokine receptors depends critically on receptor orientation [J].

Syed, RS ;

Reid, SW ;

Li, CW ;

Cheetham, JC ;

Aoki, KH ;

Liu, BS ;

Zhan, HJ ;

Osslund, TD ;

Chirino, AJ ;

Zhang, JD ;

Finer-Moore, J ;

Elliott, S ;

Sitney, K ;

Katz, BA ;

Matthews, DJ ;

Wendoloski, JJ ;

Egrie, J ;

Stroud, RM .

NATURE, 1998, 395 (6701) :511-516

[99] CYTOKINE RECEPTORS AND SIGNAL TRANSDUCTION [J].

TAGA, T ;

KISHIMOTO, T .

FASEB JOURNAL, 1992, 6 (15) :3387-3396

[100] gp130 and the interleukin-6 family of cytokines [J].

Taga, T ;

Kishimoto, T .

ANNUAL REVIEW OF IMMUNOLOGY, 1997, 15 :797-819

← 3 4 5 6 7 8 9 10 11 12 →